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Ginsenoside Rc, Ginsenoside Rb2

ginsenoside rc

CAS: 11021-14-0

Molecular Formula: C53H90O22

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Ginsenoside Rc, Ginsenoside Rb2 - Names and Identifiers

Name ginsenoside rc
Synonyms ginsenoside rc
Ginsenoside Rc
glucopyranosyl-
GINSENOSIDE RC WITH HPLC
Ginsenoside Rc, Ginsenoside Rb2
hydroxydammar-24-en-3-yl2-O-β-D-
arabinofuranosyl-β-D-glucopyranosyl)oxy]-12-
GINSENOSIDE FROM GINSENG ROOT (PANAX*QUI NQUEFOLIUM
ginsenoside-rc from panax quinquefolium (american ginseng)root
12-hydroxy-20-[(6-O-pentofuranosylhexopyranosyl)oxy]dammar-24-en-3-yl 2-O-hexopyranosylhexopyranoside
20-[(6-O-alpha-L-Arabinofuranosyl-beta-D-glucopyranosyl)oxy]-12b-hydroxydammar-24-en-3b-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
20-[(6-O-alpha-L-arabinofuranosyl-beta-D-glucopyranosyl)oxy]-12beta-hydroxydammar-24-en-3beta-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
CAS 11021-14-0
EINECS 234-253-5
InChI InChI=1/C53H90O22/c1-23(2)10-9-14-53(8,75-47-43(67)39(63)37(61)29(72-47)22-68-45-41(65)36(60)28(21-56)69-45)24-11-16-52(7)33(24)25(57)18-31-50(5)15-13-32(49(3,4)30(50)12-17-51(31,52)6)73-48-44(40(64)35(59)27(20-55)71-48)74-46-42(66)38(62)34(58)26(19-54)70-46/h10,24-48,54-67H,9,11-22H2,1-8H3

Ginsenoside Rc, Ginsenoside Rb2 - Physico-chemical Properties

Molecular FormulaC53H90O22
Molar Mass1079.27
Density1.42±0.1 g/cm3(Predicted)
Melting Point199~201℃
Boling Point1128.3±65.0 °C(Predicted)
Specific Rotation(α)(c, 1 in MeOH)+1.9
Flash Point636.2°C
Solubility H2O : 50 mg/mL (46.33 mM; Need ultrasonic)
Vapor Presure0mmHg at 25°C
AppearanceWhite powder (ethanol-n-butanol 1:5)
ColorWhite to Pale Yellow
pKa12.85±0.70(Predicted)
Storage ConditionSealed in dry,2-8°C
StabilityHygroscopic
SensitiveEasily absorbing moisture
Refractive Index1.621
MDLMFCD00133368
Physical and Chemical PropertiesWhite crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from ginseng rhizome.
In vitro study Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances γ-aminobutyric acid (GABA) receptor A (GABA A )-mediated ion channel currents. Ginsenoside Rc enhances GABA-mediated ion currents in oocytes expressing the GABA A receptor. Ginsenoside Rc significantly inhibits the expression of macrophage-derived cytokines, such as TNF-α and IL-1β. Ginsenoside Rc also markedly suppresses the activation of TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling in activated RAW264.7 macrophages, human synovial cells, and HEK293 cells. Ginsenoside Rc exerts its anti-inflammatory actions by suppressing TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling. Ginsenoside Rc suppresses the nuclear translocation of phospho-ATF-2 and phospho-FRA-1, whereas the translocation of p65 at its peak time points (30 and 60 min) is not decreased by Ginsenoside Rc treatment. Ginsenoside Rc regulates the expression of the proinflammatory cytokine TNF-α, which is produced by macrophages, by suppressing AP-1 activation.

Ginsenoside Rc, Ginsenoside Rb2 - Risk and Safety

Hazard SymbolsXn - Harmful
Harmful
Risk Codes20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
WGK Germany3
RTECSLY9536300
HS Code29389090

Ginsenoside Rc, Ginsenoside Rb2 - Reference

Reference
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2. Min Chunyan, Zhang Yuanwu Yang, et al UPLC method combined with PLS to evaluate the effect of sulfur fumigation on ginsenosides of Panax quinquefolium [J] Journal of Pharmaceutical Analysis 2018 038 (003): 432-442.
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11. Zhang Fugeng, Zhang Yu, Zhu Mingdan, et al Pharmacokinetics of ginsenosides in Qiliqiangxin Capsule in rats [J] Modern Medicine and Clinical Medicine, 2019 (8): 2268-2275.
12. Liu Ting, Xu Hong Rapid Determination of Six Saponins in Shenmai Injection by Ultrahigh Performance Liquid Chromatography [J] Medical Herald, 2016, 35 (11): 1259-1261.
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19. Yang Lin, Xu Xiaozhen, Chen Jinbai, etc Simultaneous Determination of 8 Ginsenosides in Shenmai Injection by HPLC [J] Chinese patent medicine, 2019. < br > 20. Gao Songhong, Yang Di, Li Zhongqi, Zheng Fei, Jeon You Jin, Dai Yulin. Analysis of pharmacokinetics of oral Sijunzi Decoction in type 2 diabetes rats by rapid high-resolution liquid chromatography-mass spectrometry [J]. Applied chemistry, 2021, 38 (03): 315-322. < br > 21. Wu Dongxue, Wang Qiuying, Wang Shumin, Chen Sijian, Liu Shuying, Zhao Huanxi, Xiu Yang. Biomimetic extraction of ginsenosides [J]. Analytical laboratory, 2021, 40 (02): 145-149. < br > 22. Li.Li, Zhou Yaoyao, Li Hongyan, Li Haiyan, Zhang Lei, Yue Honghong, Li Dekun, Ju Aichun. Determination of four low content ginsenosides in Yiqi Fumai (lyophilized) for injection by HPLC [J]. Drug Evaluation Research, 2020,43 (08): 1581-1586.
23. Wen Baoqing, Li Wenqing, Zhou Miaoxia, Lin Kunxia, Wang Xiaodong, Qian Zhengming. Identification and analysis of chemical components in Fushen Yin by core-shell chromatography quadrupole time-of-flight mass spectrometry [J]. Shi Zhen Traditional Chinese Medicine, 2020,31 (06): 1334-1338.
24. Zhang Na, Huang Xin, Guo Yunlong, Yue Hao, Liu Shuying. Study on the distribution of ginsenosides in different habitats based on UPLC-QQQ-MS multi index statistical analysis [J]. Specialty Research, 2020,42 (06): 48-54.
25. Shao Zijun, Li Zhiman, Yu Pengcheng, Chen Jianbo, Li Shanshan, Sun Yinshi. Effect of amino acid transformation of rare ginsenosides in Panax notoginseng flowers and its extract on lipopolysaccharide induced RAW264.7 cell activity [J]. Chinese Herbal Medicine, 2021,52 (03): 702-710.
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27. Manying Wang, Jixiang Ren, Xuenan Chen, Jianzeng Liu, Xiaohao Xu, Xiangyan Li, Daqing Zhao, Liwei Sun, 20(S)-ginsenoside Rg3 promotes myoblast differentiation and protects against myotube atrophy via regulation of the Akt/mTOR/FoxO3 pathway, Biochemical Ph
28. Zhengming Qian, Qi Huang, Chunhong Li, Jing Chen, Gang Li, Hongyan Ma & Juying Xie (2020) Analysis of ginseng root and leaf by multiple columns and detections liquid chromatography, Journal of Liquid Chromatography & Related Technologies, 43:13-14, 464-473
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34. Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi Xu,A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled wit
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Ginsenoside Rc, Ginsenoside Rb2 - Reference Information

biological activity Ginsenoside Rc is one of the main ginsenosides, Ginsenoside Rc enhances GABA receptor A (GABAA)-mediated ion channels (IGABA). Ginsenoside Rc also inhibited TNF-α and IL-1β expression.
Target TNF-α IL-1β
in vitro study Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances γ-aminobutyric acid (GABA) receptor A (GABA A )-mediated ion channel currents. Ginsenoside Rc enhances GABA-mediated ion currents in oocytes expressing the GABA A receptor. Ginsenoside Rc significantly inhibits the expression of macrophage-derived cytokines, such as TNF-α and IL-1β. Ginsenoside Rc also markedly suppresses the activation of TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling in activated RAW264.7 macrophages, human synovial cells, and HEK293 cells. Ginsenoside Rc exerts its anti-inflammatory actions by suppressing TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling. Ginsenoside Rc suppresses the nuclear translocation of phospho-ATF-2 and phospho-FRA-1, whereas the translocation of p65 at its peak time points (30 and 60 min) is not decreased by Ginsenoside Rc treatment. Ginsenoside Rc regulates the expression of the proinflammatory cytokine TNF-α, which is produced by macrophages, by suppressing AP-1 activation.
chemical properties white crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from ginseng rhizome.
use applied to the medical and health care industry, it can be formulated into anti-fatigue, anti-aging and brain-strengthening health food;
ginsenoside Rc belongs to steroid and triterpene saponins, which are unique in ginseng plants and have the growth characteristics of inhibiting or preventing tumors.
Last Update:2024-04-09 20:52:54
Ginsenoside Rc, Ginsenoside Rb2
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View History
Ginsenoside Rc, Ginsenoside Rb2
Nicotinamide Riboside Chloride(NRC)
1-Butanamine, compd. with 1,3,5-trinitrobenzene (3:1)
2-((5-bromopyridin-3-yl)oxy)ethan-1-amine
Olean-12-en-28-oic acid, 3-hydroxy-, (3β)-, mixt. with (3β)-3-hydroxyurs-12-en-28-oic acid (9CI)
(1R,5S,6S)-ETHYL 3-OXABICYCLO[3.1.0]HEXANE-6-CARBOXYLATE
[5-(4-fluorophenoxy)-1-methyl-3-phenyl-1H-pyrazol-4-yl]methyl 2-chloro-6-fluorobenzoate
2-(5-氨基吡啶-2-基)丙-2-醇
CHLOROFORMIC ACID HEPTYL ESTER
(S)-2-(((苄氧基)羰基)氨基)-4-(叔丁氧基)-2-甲基-4-氧代丁酸
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